James Perfield
223 Eckles Hall (mailing address: 256 William Stringer Wing)
(573) 882-5085 PerfieldJ@missouri.edu
Research focus:
The focus of my lab is nutrition and the physiology of metabolic disease with an emphasis on obesity and diabetes. Obesity is an independent risk factor for a number of chronic diseases. My research program aims to understand the mechanisms behind this association and to investigate potential nutritional and pharmacological therapies. Adipose tissue expansion is an inflammatory event. One objective of my lab is to further characterize the inflammatory nature of obese adipose tissue and the impact this has on other organs as well as overall metabolic status. My lab is also interested in identifying and exploiting bioactive compounds in food products with the goal of developing nutritional approaches to regulating the metabolic dysfunction associated with obesity. Ultimately, we hope to help advance the scientific community's understanding of obesity and its associated comorbidities.
Selected Professional Affiliations
The American Society for Nutrition, The Obesity Society
Selected Research Publications
K. J. Harvatine, J. W. Perfield II, and D. E. Bauman. 2009. Expression of Enzymes and Key Regulators of Lipid Synthesis are Up-Regulated in Adipose Tissue during CLA-induced Milk Fat Depression in the Dairy Cow. J. Nutr. 139:849-854 Epub Feb 11.
N. H. Rogers, J. W. Perfield II, K. J. Strissel, M. S. Obin, and A. S. Greenberg. 2009. Reduced energy expenditure and increased adipose tissue inflammation are early events in the development of ovariectomy-induced obesity and insulin resistance. Endocrinology. Epub Jan 29.
H. Miyoshi, J. W. Perfield II, M. S. Obin, and A. S. Greenberg. 2008. Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes. J. Cell. Biochem. 105:1430-1436.
D. E. Bauman, J. W. Perfield II, K. J. Harvatine, and L. H. Baumgard. 2008. Regulation of fat synthesis by conjugated linoleic acid: lactation and the ruminant model. J. Nutr. 138:403-409.
K. J. Strissel, Z. Stancheva, H. Miyoshi, J. W. Perfield II, J. DeFuria, Z. Jick, A. S. Greenberg, and M. S. Obin. 2007. Adipocyte death, adipose tissue remodeling and obesity complications. Diabetes 56:2910-2918.
J. W. Perfield II, A. L. Lock, A. Sæbø, J. M. Griinari, P. Delmonte, D. A. Dwyer, and D. E. Bauman. 2007. Trans-9, cis-11 conjugated linoleic acid (CLA) reduces milk fat synthesis in lactating dairy cows. J. Dairy Sci. 90:2211-2218.
H. Miyoshi, J. W. Perfield II, S. C. Souza, W.-J. Shen, H.-H. Zhang, Z. S. Stancheva, F. B. Kramer, M. S. Obin, A. S. Greenberg. 2007. Control of ATGL action by serine 517 of perilipin A globally regulates PKA-stimulated lipolysis in adipocytes. J. Biol. Chem. 282:996-1002.
To see more of Dr. James Perfield's publications, please visit PubMed and search for "Perfield JE."
University of Missouri Nutrition & Exercise Physiology
Faculty and Staff