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Resources for: Students | Alumni | Faculty

Grants Awarded to Faculty and Students

Below is a recent list of awards won by NEP faculty and students.

Faculty Grant Awards

Title: In the zone: an investigation into physical activity during recess

Funding Source: 2015 Margaret Mangel Award

Purpose: Increase physical activity of youth.

Title: Effects of high and low voluntary running genetics on stress and depression outcomes in females

Funding Source: Economic Development Initiative, University of Missouri Systems

Title: Integrating physical activity with numeracy in the preschool classroom

Funding Source: University of Missouri Research Council

Purpose of the Study: This pilot study aims to determine if physical activity can be integrated with preschoolers’ number learning to improve numeracy knowledge and skills.

Title: Is diabetic bone fragility caused by preferential differentiation of bone stem cells into fat rather than bone?

Funding Source: Margaret Mangel Research Catalyst Award

Purpose: The overall goal of this project is to investigate whether decreased osteoblastogenesis due to preferential differentiation of MSC into adipocytes is a mechanism by which bone fragility is increased with obesity and type 2 diabetes.

Title: Dawn phenomena: lowering impaired fasting glucose levels with exercise

Funding Source: National Institute of Health

Purpose: This project will compare EGP, β-cell function and hormonal responses between morning and evening exercise on the postprandial and overnight period in obese individuals with/without IFG levels.

Title: Effect of high-protein diet on postprandial glucose levels and insulin sensitivity following a transition from high to low physical activity

Funding Source: American Egg Board

Purpose: The goal of this project is to determine if diet composition can alter the deleterious responses in postprandial glucose and insulin sensitivity during periods of physical inactivity.

Title: Targeting endoplasmic reticulum stress to correct vascular insulin resistance and glycemic dysregulation in diabetes

Funding Source: Department of Health and Human Services, National Institutes of Health

Title: Vascular insulin resistance in obesity: Role of endoplasmic reticulum stress

Funding Source: National Institute of Health K01

Title: Vasomotor effects of perivascular adipose tissue: Role of UCP-1

Funding Source: Cardiometabolic Disease Research Foundation

Title: Role of uncoupling protein 1 in the protection against juvenile obesity, insulin resistance and cardiovascular risk

Funding Source: Sears Trust Foundation

Title: A short term evaluation of a structured weight loss plan in overweight and obese adults

Funding Source: Industry Award

Purpose: This is a study of the impact of restricting dietary sugars in overweight men and women. We will test the hypothesis that women respond better than men with regard to improvements in blood pressure when they lose weight.

Title: Gender differences in the metabolic effects of uric acid reduction: A pilot study

Funding Source: MU Department of Medicine

Purpose: This study will determine the effect of treatment using a drug, Allopurinol, to lower a molecule in the blood called uric acid. Uric acid is thought to cause a stiffening of blood vessels. We hypothesize that women will improve their blood vessel stiffness better than men when the concentration of blood uric acid is lowered.

Title: Gender differences in the metabolic effects of uric acid

Funding Source: MU Research Council

Purpose: This project studies overweight women at risk for developing heart disease. Dietary fructose is thought to increase a marker in the blood called uric acid. Our plan is to remove the fructose from the womens' diets and replace it with starch to determine whether this treatment reduces blood uric acid and reduces their heart disease risk.

Title: Hepatocellular eNOS and Fatty Liver Disease

Funding Source: Missouri Foundation for Medical Research

Purpose: The goal of this project is to examine the role of hepatic endothelial nitric oxide synthase in the progression of NASH.

Title: Effect of Uncoupling Protein 1 on Ovariectomy-Associated Metabolic Dysfunction

Funding Source: University of Missouri Research Council

Purpose: The objective of this grant is to determine if UCP-1 knock out (KO) rodents have an exacerbated cardio-metabolic response to ovariectomy (OVX). We hypothesize that UCP1KO mice will exhibit exacerbated gains in fat mass, reduced energy expenditure, insulin resistance, and cardiovascular dysfunction compared to control mice and that this will relate to molecular changes in brown and white adipose tissue.

Title: Effect of Uncoupling Protein 1 in the Sexual Dimorphism of Metabolic Response to High Fat Diet

Funding Source: University of Missouri Richard Wallace Fund

Purpose: The purpose of this study is to determine the role played by UCP-1, using a rodent whole body gene knock-out (KO) model, in the sex difference in the metabolic response to high fat diet (HFD). Aim 1 will characterize the metabolic response to HFD in male versus female UCP-1 KO and wild-type mice; Aim 2 will determine if the sexual dimorphism in the metabolic response to HFD is related to molecular changes in adipose tissue.

Title: Fat depot specific effects of physical activity in obese juvenile rats

Funding Source: University of Missouri Research Board

Purpose: The aim of this grant is to determine the effect of physical activity (PA) on adipose tissue (AT) immune cell populations and insulin sensitivity in a rat model of juvenile obesity. Its focus is on the effects of PA on AT immune cell composition and insulin sensitivity across 4 depots: brown (BAT), PVAT, subcutaneous (SQAT), and visceral (VAT). This work will determine the AT depot-specific immunological and metabolic effects of voluntary PA in obese juvenile rats, and determine if the effects of PA on AT metabolic function are contingent upon changes in total adiposity.

Graduate Student Grant Awards

Title: Short-term exercise training and postprandial glycemic control in type 2 diabetes

Funding Source: American College of Sports Medicine

Purpose: The primary purpose of this study was to address the hypothesis that short-term exercise training lowers postprandial glycemic excursions and improves glycemic control due primarily to enhanced glucose disposal and decreased hepatic glucose output. Secondarily, we also compared measures of glycemic control from a mixed meal tolerance test (MMTT), a lab-based test designed to mimic the free-living condition, to the standard lab-based measure, the oral glucose tolerance test (OGTT), to determine if the MMTT is a better tool to illustrate changes in postprandial glycemic control which occur following short-term exercise training.

Title: Interaction between diet composition and physical inactivity on insulin sensitivity and β-cell function

Advised by: Dr. Jill Kanaley

Funding Source: American Egg Board

Purpose: To determine whether high protein feeding protects against the metabolic perturbations of physical inactivity (i.e. increased postprandial glucose, hyperinsulinemia, and decreased insulin sensitivity).